GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs2412488 | 1 | rs6554106 | chr4:54292791 | SCFD2 | chr4:53739152-54232242:- | 0.2 | 3.92 | 0.000101 | DNA methylation (variation) |
| THCA | cis | rs6832769 | 1 | rs6554286 | chr4:56400304 | TMEM165 | chr4:56262090-56292342:+ | 0.15 | 3.78 | 0.000176 | Personality dimensions |
| THCA | cis | rs12602901 | 1 | rs6559 | chr17:4848450 | GP1BA | chr17:4835592-4838324:+ | -0.21 | -3.65 | 0.000296 | Blood metabolite levels |
| THCA | cis | rs12602901 | 1 | rs6559 | chr17:4848450 | SLC25A11 | chr17:4840605-4843325:- | -0.16 | -4.27 | 2.38E-5 | Blood metabolite levels |
| THCA | cis | rs12602901 | 1 | rs6559 | chr17:4848450 | VMO1 | chr17:4688581-4689729:- | 0.17 | 3.35 | 0.000876 | Blood metabolite levels |
| THCA | cis | rs6560517 | 1 | rs6560517 | chr9:79038170 | GCNT1 | chr9:79034752-79122330:+ | 0.15 | 3.46 | 0.000584 | Dialysis-related mortality |
| THCA | cis | rs6560517 | 1 | rs6560517 | chr9:79038170 | PCSK5 | chr9:78505560-78808338:+ | 0.15 | 3.39 | 0.00077 | Dialysis-related mortality |
| THCA | cis | rs6560517 | 1 | rs6560517 | chr9:79038170 | RFK | chr9:79000433-79009444:- | 0.18 | 3.82 | 0.000152 | Dialysis-related mortality |
| THCA | cis | rs2149423 | 1 | rs6563380 | chr13:36770422 | SOHLH2 | chr13:36742347-36871992:- | 0.36 | 6.23 | 1.02E-9 | Glucose homeostasis traits |
| THCA | cis | rs7116495 | 1 | rs656640 | chr11:71781710 | FAM86C | chr11:71498557-71512276:+ | 0.31 | 3.81 | 0.000158 | Severe influenza A (H1N1) infection |
| THCA | cis | rs6686842 | 1 | rs656917 | chr1:41569708 | SCMH1 | chr1:41492875-41707788:- | 0.2 | 4.66 | 4.14E-6 | Height |
| THCA | cis | rs568617 | 1 | rs656980 | chr11:65656282 | CTSW | chr11:65647284-65651212:+ | -0.6 | -15.88 | 6.69E-46 | Crohn's disease |
| THCA | cis | rs568617 | 1 | rs656980 | chr11:65656282 | SNX32 | chr11:65601410-65621170:+ | 0.63 | 9.47 | 1.33E-19 | Crohn's disease |
| THCA | cis | rs947583 | 1 | rs6570043 | chr6:136134098 | C6orf217 | chr6:135818939-136037192:+ | -0.36 | -10.1 | 7.29E-22 | Phosphorus levels |
| THCA | cis | rs11962089 | 1 | rs6571221 | chr6:105621189 | BVES | chr6:105544700-105585049:- | 0.23 | 3.78 | 0.000179 | Multiple sclerosis |